Fixed: outbound message rejected due to spam or virus
Solved: All my email to optimum users is being blocked by spam filter
Incoming email being rejected as Spam
Email to SMS (aquacool.co.nz) is blocking our domain for spam.
550 5.7.1 Message rejected due to content restrictions in Exchange Online Protection
So is it blocking based on the o365 server ip? There is nothing you need to do to enable the spam and virus protection.
I wouldn't expect this to be a widespread problem though.
If your email was blocked, a spam filter may have interpreted the campaign content as spam.